Xuchen Zhang

Spatial Glyco-Codes Define Human Liver Pathology and Progression

This study introduces spatial-GPT, a platform for spatial glycan, protein, and transcriptome profiling in human liver tissues, revealing glyco-codes that define disease states and progression.

Single-cell spatial multi-omics molecular pathology enabled by SuperFocus

SuperFocus integrates histopathology with single-cell spatial multi-omics data from spot-based measurements, improving accuracy by 28-73% over existing methods.

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages

This study shows that increased VCAM-1 in hepatic artery endothelial cells and portal fibroblasts recruits Spp1+ macrophages, driving fibrosis in portal hypertension.

Prevalence, Production and the Role of Staphylococcus aureus Superantigens in Cystic Fibrosis Lung Disease.

This study investigates the prevalence and role of Staphylococcus aureus superantigens in CF lung disease, showing their ability to induce inflammatory responses in mouse models.

Liver Lymphatic Dysfunction as a Driver of Fibrosis and Cirrhosis Progression

This study shows that impaired liver lymphatic function drives fibrosis and cirrhosis progression and identifies VEGF-C as a potential therapeutic target.