A circRNA-based uricase replacement therapy for sustained treatment of hyperuricemia
Zheyu Zhang, Jiewen Zhong, Kai Zhang, Jiang Hu, Yun Yang, Zefeng Wang
This study develops a circRNA-based uricase replacement therapy that reduces serum urate levels and maintains efficacy for up to 10 weeks in uricase-knockout mice.
bioRxiv · Mar 20, 2026 · PreprintMolecular Biology