Author

Kai Zhang

East China Normal UniversityORCID 0000-0001-6297-4423Unclaimed ORCID profile · follow to get notified of new preprints

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Kai Zhang19 papers · Virginia Commonwealth University

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Baoli wang· 1 shared Changzhi Sun· 1 shared Chenglin WangiD· 1 shared Danlin Liu· 1 shared Honglin LiiD· 1 shared Jiang HuiD· 1 shared Jie ZhangiD· 1 shared Jiewen Zhong· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioinformatics

Baoli wang

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMar 20, 2026

A circRNA-based uricase replacement therapy for sustained treatment of hyperuricemia

Zheyu Zhang, Jiewen Zhong, Kai Zhang…·Zefeng Wang

This study develops a circRNA-based uricase replacement therapy that reduces serum urate levels and maintains efficacy for up to 10 weeks in uricase-knockout mice.

DOI 10.64898/2026.03.19.712815

mouseexperimental assay

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BioinformaticsNature Machine IntelligencePeer-reviewedFeb 25, 2026

Conditional Diffusion with Locality-Aware Modal Alignment for Generating Diverse Protein Conformational Ensembles

Baoli wang, Chenglin Wang, Jingyang Chen…·Honglin Li

This paper introduces Mac-Diff, a diffusion model that generates diverse protein conformations by aligning sequence and geometry views, showing improved recovery of conformational distributions and meta-stable states.

5 citationstop 2%

protein structurediffusion model

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