Classical enhancers couple cis-regulatory logic with transcriptional condensates and 3D genome architecture
Ville Tiusanen, Divyesh Patel, Jihan Xia, Chi Xu, Subhamoy Datta, Ji Weon Yun, Samuele Cancellieri, Liangru Fei, Mehmet Yilmaz, Esa Pitkänen, Stefan Preković, Päivi Pihlajamaa, Biswajyoti Sahu
The paper shows classical enhancers influence 3D genome structure by linking DNA sequence to transcriptional condensates and chromatin organization through specific transcription factors.
bioRxiv · Jan 23, 2026 · PreprintGenomics