Biswajyoti Sahu

This study shows that mitochondrial DNA replication defects in skeletal muscle alter methylation patterns of phospholipids, histones, and RNA, linking mitochondrial dysfunction to methylation remodeling in mitochondrial myopathy.

The paper identifies NFATC2-expressing cancer-associated fibroblasts in PDAC that improve treatment response and enhance ERBB-targeted therapies.

The paper shows classical enhancers influence 3D genome structure by linking DNA sequence to transcriptional condensates and chromatin organization through specific transcription factors.

This study develops IonStats, a toolkit for profiling DNA adducts using nanopore sequencing, revealing compound-specific effects on sequencing data.

This study shows KSHV uses SOX18 to maintain viral episomes in LECs by enhancing chromatin accessibility.

The paper identifies tissue-specific transposable element enhancers in colorectal and liver cancers using unbiased reporter assays and shows their association with distinct transcription factors and differentially expressed genes.

The paper identifies sequence determinants of human gene regulatory elements by analyzing transcriptional activity of long DNA sequences in three cell types, revealing distinct enhancer types and TF subtypes based on motif content and activity patterns.

This study uses a novel competitive genome editing assay to identify MYC oncogene transcriptional targets by analyzing the effects of E-box mutations on cellular fitness.

This study shows that combining oncogenes with lineage reprogramming can transform human cells into tumorigenic liver-like cells.

The paper investigates how transcription factors interact with nucleosomal DNA, finding that most have less access to it than free DNA and that nucleosome structure affects motif positioning and orientation.

The paper introduces ATI, a method to measure TF DNA-binding activity, and finds that few TFs with strong binding activity determine open chromatin.