Subhamoy Datta

Classical enhancers couple cis-regulatory logic with transcriptional condensates and 3D genome architecture

The paper shows classical enhancers influence 3D genome structure by linking DNA sequence to transcriptional condensates and chromatin organization through specific transcription factors.

CGGBP1 from higher amniotes restricts cytosine methylation and drives a GC-bias in transcription factor binding sites at repressed promoters

This paper shows that CGGBP1 from higher amniotes restricts cytosine methylation and maintains GC-rich transcription factor binding sites in repressed promoters, influencing TFBS evolution.

The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression

This study shows CGGBP1's DNA-binding domain prevents cytosine methylation at transcription factor binding sites in promoters, regulating gene expression and evolving as a key mechanism in vertebrates.

G-quadruplex landscape and its regulation revealed by a new antibody capture method

The paper introduces a new antibody capture method to accurately capture G4 structures in human cells and shows that G4 formation is constrained by sequence properties and nuclear environment.

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1.

The paper investigates chromosomal chimeras in human cell cultures, showing their occurrence at genomic repeats and regulation by stress and CGGBP1 depletion.

CGGBP1-dependent CTCF-binding sites restrict ectopic transcription

The paper shows CGGBP1-dependent CTCF-binding sites inhibit ectopic transcription from the SV40 promoter by acting as transcription barriers.

CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity

The paper shows that CGGBP1 regulates cytosine methylation at CTCF-binding sites deterministically, influencing CTCF occupancy and function.

CGGBP1 regulates chromatin barrier activity and CTCF occupancy at repeats

This study shows CGGBP1 regulates CTCF occupancy at repeats and their chromatin barrier function through ChIP-sequencing and histone modification analysis.