Author

Ville Tiusanen

University of HelsinkiORCID 0009-0002-9681-9696Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:DNA methylation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Biswajyoti SahuiD· 3 shared Adam T. GrundhoffiD· 1 shared Alexey V. TerskikhiD· 1 shared Anastasiia MarmylevaiD· 1 shared Anu SuomalaineniD· 1 shared Chi Xu· 1 shared Divyesh PateliD· 1 shared Elizabeth HindeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMolecular Biology

Biswajyoti SahuORCID

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3 papers

Recent·Most cited

Mitochondrial dysfunction reshapes methyl-group allocation inskeletal muscle

Anastasiia Marmyleva, Ville Tiusanen, Priit Jõers, Biswajyoti Sahu, Anu Suomalainen

This study shows that mitochondrial DNA replication defects in skeletal muscle alter methylation patterns of phospholipids, histones, and RNA, linking mitochondrial dysfunction to methylation remodeling in mitochondrial myopathy.

bioRxiv · Aug 24, 2026 · PreprintMolecular Biology

Classical enhancers couple cis-regulatory logic with transcriptional condensates and 3D genome architecture

Ville Tiusanen, Divyesh Patel, Jihan Xia, Chi Xu, Subhamoy Datta, Ji Weon Yun, Samuele Cancellieri, Liangru Fei, Mehmet Yilmaz, Esa Pitkänen, Stefan Preković, Päivi Pihlajamaa, Biswajyoti Sahu

The paper shows classical enhancers influence 3D genome structure by linking DNA sequence to transcriptional condensates and chromatin organization through specific transcription factors.

bioRxiv · Jan 23, 2026 · PreprintGenomics

Oncogenic virus hijacks SOX18 pioneer function to enhance viral persistence

Krista Tuohinto, Matthew S. Graus, Peyton Staab, Ville Tiusanen, Fei Liangru, Susav Pradhan, Yew Yan Wong, Simon Weissmann, Jieqiong Lou, Elizabeth Hinde, Justin Wong, Quintin Lee, Alexey V. Terskikh, Martin Alvarez-Kuglen, Tara Karnezis, , Päivi M. Ojala

This study shows KSHV uses SOX18 to maintain viral episomes in LECs by enhancing chromatin accessibility.

bioRxiv · Jun 28, 2025 · PreprintMolecular Biology