Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs
Yu Huining Sun, Ruoqiao Huiyi Wang, Khai Du, Jiang Zhu, Jihong Zheng, Li Huitong Xie, Amanda A. Pereira, Chao Zhang, Emiliano P. Ricci, Xin Zhiguo Li
The paper shows that ribosomes guide piRNA production from mRNAs in 3UTRs after translating upstream long ORFs, revealing a conserved mechanism for piRNA biogenesis.
Nature Communications · Oct 13, 2021Peer-reviewedMolecular Biology