Dual effects of ARX poly-alanine mutations in human cortical and interneuron development
Vanesa Nieto‐Estévez, Parul Varma, Sara Mirsadeghi, Jimena Caballero, Sergio Gamero-Alameda, Ali Hosseini, Marc Joshua Silvosa, Drew M. Thodeson, Zane R. Lybrand, Michèle Giugliano, Christopher S. Navara, Jenny Hsieh
This study investigates the effects of ARX poly-alanine mutations in human brain organoids, revealing altered interneuron migration and cortical neuron development.
bioRxiv · Jan 25, 2024 · PreprintNeuroscience