Michèle Giugliano

Lifelong prion protein (PrP) loss in mice lowers excitatory synaptic proteins, makes network bursts in mature cortical cultures rarer and neuronal activity more correlated, and increases adult dimming-disk escapes.

This study shows APOE4 affects cortical neurodevelopment and network formation in human brain organoids by altering cell types, increasing cell death, and disrupting GABA signaling.

This study investigates the effects of ARX poly-alanine mutations in human brain organoids, revealing altered interneuron migration and cortical neuron development.

This paper investigates how ionic actuation of potassium can modulate neuronal excitability using theoretical models and simulations, showing bidirectional effects on neural activity.

The paper shows that plasticity of inhibitory synapses onto layer 5 pyramidal neurons modulates excitation-inhibition ratios, neuronal gain, and information transfer across cortical layers.

This study examines how the absence of FMRP affects neuronal network development in an in vitro model, finding that network-level changes are more pronounced than single-cell alterations.

The paper links human intelligence to neuronal complexity and action potential speed in pyramidal neurons using brain tissue and imaging data.

This study investigates the effects of inhibiting Urokinase Plasminogen Activator and Neuropsin on neuronal network activity in vitro, finding altered bursting dynamics and connectivity at high inhibitor concentrations.