Maladaptive inflammatory signaling in old mice impairs colonic regeneration by promoting a sustained fetal-like epithelial state
Antonion Korcari, Helen M. Tauc, Jeff Duggan, Fabien Wehbe, Spyros Darmanis, Zora D. Modrusan, Jina Yun, Rajita Pappu, David Garfield, Heinrich Jasper, David Castillo‐Azofeifa
This study identifies how aging impairs colonic regeneration in mice by promoting a fetal-like epithelial state through sustained IFNγ signaling.
Aging Cell · Apr 20, 2026Peer-reviewedImmunology