Author

David Castillo‐Azofeifa

GenentechORCID 0000-0001-9121-4829Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Developmental Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ophir D. KleiniD· 2 shared Antonion KorcariiD· 1 shared Belkis J. JacqueziD· 1 shared David Garfield· 1 shared Diane L. BarberiD· 1 shared Efren A. ReyesiD· 1 shared Erin Jennifer Golden· 1 shared Fabien WehbeiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersDevelopmental Biology

Ophir D. KleinORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologyAging CellPeer-reviewedApr 20, 2026

Maladaptive inflammatory signaling in old mice impairs colonic regeneration by promoting a sustained fetal-like epithelial state

Antonion Korcari, Helen M. Tauc, Jeff Duggan…·David Castillo‐Azofeifa

This study identifies how aging impairs colonic regeneration in mice by promoting a fetal-like epithelial state through sustained IFNγ signaling.

1 citation

𝕏 PostBluesky

Developmental BiologyNature CommunicationsPeer-reviewedJun 23, 2023

Intracellular pH dynamics regulates intestinal stem cell lineage specification

Yi Liu, Efren A. Reyes, David Castillo‐Azofeifa…·Diane L. Barber

The paper shows that intracellular pH dynamics regulate intestinal stem cell lineage specification by promoting secretory or absorptive differentiation depending on pH levels.

30 citationstop 3%

𝕏 PostBluesky

Developmental BiologyDevelopmentPeer-reviewedJun 26, 2018

SOX2 Regulation by Hedgehog Signaling Controls Adult Lingual Epithelium Homeostasis

David Castillo‐Azofeifa, Kerstin Seidel, Lauren Gross…·Linda A. Barlow

This study shows that SOX2, regulated by Hedgehog signaling, is essential for maintaining adult lingual epithelium homeostasis, including taste bud differentiation and epithelial cell balance.

29 citations

mousestatistical model

𝕏 PostBluesky