Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimers disease
Jong Shin, Nandita Joshi, B Miller, Shams Vellarikkal, Jianhua Huang, Fan Wu, Yi Cui, Aparna Murali, Joshua Chason, Christopher Scott Campbell, Khoi Chu, Reza Roozafzoon, Mark Dostalík, Jindřich Soukup, Gina Savastano, , Bilal Çakır
This study shows that amyloid plaques disrupt oligodendrocyte proteostasis, leading to myelin loss in Alzheimer's disease.
bioRxiv · Aug 6, 2026 · PreprintNeuroscience