BioengineeringbioRxiv
In vivo affinity maturation of the HIV-1 Env-binding domain of CD4
Andi Pan, Charles C. Bailey, Tianling Ou…·Wenhui He
This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.
DOI 10.1038/s41551-024-01289-1