Author

Charles C. Bailey

Broad InstituteORCID 0000-0003-0200-3523Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Gogce C. CryneniD· 2 shared Huihui MouiD· 2 shared Michael FarzaniD· 2 shared Andi PaniD· 1 shared Baodan Hu· 1 shared Bo Gao· 1 shared Chao WangiD· 1 shared Claire E. KitzmilleriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMicrobiology

Gogce C. CrynenORCID

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2 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedOct 27, 2026

A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation

Huihui Mou, Bo Gao, Gang Ye…·Hyeryun Choe

This paper describes a trimeric inhibitor, S22, that stabilizes the SARS-CoV-2 spike protein in a closed conformation, preventing ACE2 binding and viral entry.

DOI 10.1038/s41467-026-78835-9

humanstructural biology

𝕏 PostBluesky

BioengineeringNature Biomedical EngineeringPeer-reviewedDec 5, 2024

In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

Andi Pan, Charles C. Bailey, Tianling Ou…·Wenhui He

This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.

15 citations

mouseproteomics

𝕏 PostBluesky