Paternal Metabolic Reversal Remodels Sperm RNA Profiles and Ameliorates Intergenerational Metabolic Disorder in Mice
Sheng Chen, Rubens Daniel Miserani Magalhães, Zhuqing Wang, Fritz Cayabyab, Jinhyuk Choi, Eiji Yoshihara, Rui Wang, Hayden McSwiggin, Laura Chávez, Harry B. Rossiter, Rachelle Bross, Yanhe Lue, Christina Wang, Ronald S Swerdloff, John Robert McCarrey, , Wei Yan
This study shows that paternal metabolic recovery before conception remodels sperm RNA and reduces transmission of HFD-associated metabolic risk to offspring in mice.
bioRxiv · Aug 6, 2026 · PreprintGenetics