Wei Yan

This study shows mammalian sperm use cytoplasmic droplets and mitochondria for protein synthesis during epididymal maturation, overcoming transcriptional silence to achieve motility and fertility.

This study shows that paternal metabolic recovery before conception remodels sperm RNA and reduces transmission of HFD-associated metabolic risk to offspring in mice.

The paper identifies fallopian tube progenitors as potential precursors of high-grade serous ovarian cancer by integrating transcriptomic data from normal and malignant tissues.

This study maps neuroimmune transcriptomic changes in the lung during asthmatic induction, showing altered gene expression in specific cell clusters and spatial locations.

This study shows perinatal nicotine exposure increases DNA methylation in the angiotensin II type 1 receptor gene in carotid bodies, enhancing angiotensin signaling and leading to hypertension.

This study shows that the X-linked miR-506 family miRNAs enhance sperm competitiveness and male reproductive fitness by fine-tuning gene expression during spermatogenesis.

AASRA is a small RNA annotation pipeline that improves accuracy and speed by handling sncRNA variants and distinguishing mature from precursor miRNAs.

The paper identifies miRNA-dependent poly(A) length regulation as a mechanism for uncoupling transcription and translation in spermatids.

The paper analyzes HRSV circulation in Huzhou, China, from 2016 to 2019, finding co-circulation of subgroups A and B with highest infection rates in infants.

This study shows that miR-465 cluster ablation causes female conceptus degeneration and a male-biased sex ratio in mice, indicating a sexual dimorphism in placental development.

The paper investigates the role of DNMT2 in maternal transmission of a paramutant phenotype through the male germline.

This study compares operant learning and memory between mice born via ICSI and naturally-conceived controls, finding sex-specific deficits in ICSI mice.

This study demonstrates that CRISPR-Mb3Cas12a can efficiently edit the mouse genome with minimal off-target effects and without requiring the TTTV PAM sequence.

The paper identifies artificial junction sequences formed by reverse transcriptases, leading to false circular RNA identification, and proposes methods to distinguish true circular RNAs.