Author

Sheng Chen

The Lundquist Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Bioinformatics· 1 Biophysics· 1 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Hayden McSwigginiD· 2 shared Huili ZhengiD· 2 shared Rubens Daniel Miserani MagalhãesiD· 2 shared Wei YaniD· 2 shared Zhuqing WangiD· 2 shared Anne Elizabeth Yan· 1 shared Bing HeiD· 1 shared Brian NguyeniD· 1 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Hayden McSwigginORCID

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Author profile →

4 papers

Recent·Most cited

Life without cytoplasm: sperm sustain protein production utilizing cytoplasmic droplets and mitochondria as translational apparatuses

Zhuqing Wang, Hetan Wang, Rubens Daniel Miserani Magalhães, Sheng Chen, Siying Meng, Dayton Morris, Sarah Crane, Hayden McSwiggin, Anne Elizabeth Yan, Saayli Khambekar, Brian Nguyen, Huili Zheng, Wei Yan

This study shows mammalian sperm use cytoplasmic droplets and mitochondria for protein synthesis during epididymal maturation, overcoming transcriptional silence to achieve motility and fertility.

bioRxiv · Aug 11, 2026 · PreprintCell Biology

Optimizing broadly neutralizing antibodies via all-atom interaction modeling and pre-trained language models

Yidong Song, Fandi Wu, Rubo Wang, Wei Zheng, Bing He, Qihong Yan, Xiaohan Huang, Yuquan Li, Sheng Chen, Qianmu Yuan, Jiahua Rao, Zhenchao Tang, Jiale Zhou, Haohuai He, Jincun Zhao, , Jianhua Yao

This paper introduces InterAb and InterAb-Opt, computational frameworks that predict and optimize broadly neutralizing antibodies using all-atom modeling and pre-trained language models, showing significant improvements in binding affinity and neutralization activity.

bioRxiv · Aug 7, 2026 · PreprintBioinformatics

Paternal Metabolic Reversal Remodels Sperm RNA Profiles and Ameliorates Intergenerational Metabolic Disorder in Mice

Sheng Chen, Rubens Daniel Miserani Magalhães, Zhuqing Wang, Fritz Cayabyab, Jinhyuk Choi, Eiji Yoshihara, Rui Wang, Hayden McSwiggin, Laura Chávez, Harry B. Rossiter, Rachelle Bross, Yanhe Lue, Christina Wang, Ronald S Swerdloff, John Robert McCarrey, , Wei Yan

This study shows that paternal metabolic recovery before conception remodels sperm RNA and reduces transmission of HFD-associated metabolic risk to offspring in mice.

bioRxiv · Aug 6, 2026 · PreprintGenetics

Absolute hand determination of glycofibrils from natural sources in cryo-EM

Qi Zhang, Li Qin, Tongtong Wang, Zhangqiang Li, Yilin Zhang, Sheng Chen, Qijun Ge, Jialing Wen, Nieng Yan, Jiawei Wang, Mingxu Hu

This study introduces Ahaha, a method for determining absolute hand of glycofibrils in cryo-EM, enabling atomic model building from natural sources.

Proceedings of the National Academy of Sciences · Feb 25, 2026Peer-reviewedBiophysics