Zhuqing Wang

Life without cytoplasm: sperm sustain protein production utilizing cytoplasmic droplets and mitochondria as translational apparatuses

This study shows mammalian sperm use cytoplasmic droplets and mitochondria for protein synthesis during epididymal maturation, overcoming transcriptional silence to achieve motility and fertility.

Paternal Metabolic Reversal Remodels Sperm RNA Profiles and Ameliorates Intergenerational Metabolic Disorder in Mice

This study shows that paternal metabolic recovery before conception remodels sperm RNA and reduces transmission of HFD-associated metabolic risk to offspring in mice.

Epigenetic upregulation of carotid body angiotensin signaling increases blood pressure

This study shows perinatal nicotine exposure increases DNA methylation in the angiotensin II type 1 receptor gene in carotid bodies, enhancing angiotensin signaling and leading to hypertension.

The Rapidly Evolving X-linked miR-506 Family Finetunes Spermatogenesis to Enhance Sperm Competition

This study shows that the X-linked miR-506 family miRNAs enhance sperm competitiveness and male reproductive fitness by fine-tuning gene expression during spermatogenesis.

miRNA-dependent poly(A) length control in uncoupling transcription and translation of haploid male germ cells

The paper identifies miRNA-dependent poly(A) length regulation as a mechanism for uncoupling transcription and translation in spermatids.

A sexual dimorphic role of the miR-465 cluster in placental development

This study shows that miR-465 cluster ablation causes female conceptus degeneration and a male-biased sex ratio in mice, indicating a sexual dimorphism in placental development.

Efficient multiplex genome editing using CRISPR-Mb3Cas12a in mice

This study demonstrates that CRISPR-Mb3Cas12a can efficiently edit the mouse genome with minimal off-target effects and without requiring the TTTV PAM sequence.

Template switching causes artificial junction formation and false identification of circular RNAs

The paper identifies artificial junction sequences formed by reverse transcriptases, leading to false circular RNA identification, and proposes methods to distinguish true circular RNAs.