Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitability
Yeon Ha Ju, Janet Yinqing Zhao, Setareh Sianati, Christine Egebjerg, Oscar Christian Gonzalez, Abby Criswell, Chaeyun Yuni Lee, Kaitlyn Du, Charlotte Luff, Joanna Stralka, Valentina Knapp, Luı́s de Lecea, Yevgenia Kozorovitskiy, Julie A. Kauer, Lief E. Fenno
This study uses CRISPR/Cas9 to knock down Clock in mouse VTA dopamine neurons, revealing effects on sleep, behavior, and excitability linked to bipolar disorder.
bioRxiv · Jun 25, 2026 · PreprintNeuroscience