Oscar Christian Gonzalez

This study uses CRISPR/Cas9 to knock down Clock in mouse VTA dopamine neurons, revealing effects on sleep, behavior, and excitability linked to bipolar disorder.

This paper uses a biophysically realistic network model to show how sleep replay reorganizes synaptic-weight space to support both old and new memories.

This study uses a computational model to show that ion dynamics underlie the temporal structure of resting-state functional connectivity.

This paper shows that slow-wave sleep interleaves replay of familiar and novel memory traces, enabling new memories to integrate into existing cortical memory without interference.

This study identifies neuronal senescence in dorsal root ganglia of aged and injured mice, showing it contributes to sensory dysfunction and is reversible with senolytic treatment.

The paper develops a biophysically realistic human brain model to study how synaptic connectivity influences the emergence of global and local slow waves during slow-wave sleep.

The paper identifies phosphorylated pyruvate dehydrogenase (pPDH) as an in vivo marker for neuronal inhibition, correlating with reduced action potential firing and detectable across various inhibitory conditions.

This study shows that sleep replay helps protect old memories from being lost when new memories are learned, by reorganizing synaptic connections to support both memories.

This study shows that slow brain fluctuations in resting states arise from ion concentration dynamics modeled in a computational brain network.

This study investigates how varying concentrations of 4-aminopyridine (4AP) affect hippocampal epileptiform activity in mouse brain slices, showing dose-dependent changes in frequency and spatio-temporal patterns.

This study investigates the role of KCC2-dependent potassium efflux in 4-aminopyridine-induced epileptiform synchronization through experiments and a biophysically realistic network model.