Yevgenia Kozorovitskiy

This study identifies three functional programs impacted by autism genes, contextualized across neuronal subclasses, developmental timing, and cortical regions.

The paper maps the proteomic changes in midbrain dopamine axons during postnatal development, identifying temporal dynamics of protein expression and linking them to disease risk.

This study identifies LRRK2's role in impairing dopamine axon release sites in Parkinson's disease, leading to reduced dopamine release and synaptic dysfunction.

This study uses CRISPR/Cas9 to knock down Clock in mouse VTA dopamine neurons, revealing effects on sleep, behavior, and excitability linked to bipolar disorder.

This study shows that neural synchrony in prairie voles is influenced by bond strength, distance, and interaction time, and is shaped by relationship history.

This paper develops a wireless transcranial optogenetic system to generate artificial perceptions in mice through controlled cortical stimulation and demonstrates its effectiveness in operant learning tasks.

This study shows that LRRK2 kinase mediates haloperidol-induced motor side effects in striatal neurons, suggesting LRRK2 as a target to reduce antipsychotic side effects.

This paper introduces a microfluidic and fluorescence platform for in vivo neuropharmacology, enabling drug delivery and neural activity monitoring in rodent brains.

The paper analyzes striatal ensemble activity during self-grooming in mice, identifying functional ensembles that show distinct grooming-related dynamics.

The paper maps the cell-type specific proteome and phosphoproteome of corticostriatal axons across postnatal development, identifying proline-directed kinases as key developmental regulators.

This study identifies Drd1 dopamine receptors in unipolar brush cells and shows that dopamine from locus coeruleus axons modulates their activity, forming a dopamine-sensitive circuit with Purkinje neurons.

The paper maps synaptic inputs and outputs of paraventricular oxytocin and vasopressin neurons in mice, revealing sex-conserved inputs and sex-differentiated outputs.

This study identifies the Edinger-Westphal nucleus in mice as an obligately peptidergic population that modulates fear responses and analgesia.

Crossbill is an open-access single objective light-sheet microscopy platform that provides high-resolution, affordable volumetric imaging in zebrafish and mouse brain sections.

The paper develops a method to profile cell-type specific subcellular proteomes in the mouse brain using APEX2 proximity labeling.

This study investigates how LRRK2 mutations affect synaptic structure and function in striatal neurons, revealing pathway-specific changes that may contribute to Parkinson's disease.

This study shows ketamine restores escape behavior by re-engaging dopamine systems to drive cortical spinogenesis after aversive learning.

This paper develops a method to create photoactivatable nicotine for optopharmacology studies of nicotinic acetylcholine receptors.