Luı́s de Lecea

This study uses CRISPR/Cas9 to knock down Clock in mouse VTA dopamine neurons, revealing effects on sleep, behavior, and excitability linked to bipolar disorder.

This study identifies neuronal senescence in dorsal root ganglia of aged and injured mice, showing it contributes to sensory dysfunction and is reversible with senolytic treatment.

The paper identifies phosphorylated pyruvate dehydrogenase (pPDH) as an in vivo marker for neuronal inhibition, correlating with reduced action potential firing and detectable across various inhibitory conditions.

This study identifies neural circuits in the hypothalamus that regulate torpor by mapping torpor-activated neurons and analyzing their connectivity.

This study shows that Bmal1 deficiency in myeloid cells disrupts microglial synaptic pruning, accelerates cognitive aging, and affects sleep-wake cycles in mice.

The paper presents a matrix-based method to infer arousal state by integrating neural, metabolic, and immune system data.

This study identifies hypothalamic circuitry involved in stress-induced insomnia and immunosuppression using genetic and optogenetic approaches.

This study shows that adolescent sleep disruption impairs adult social novelty preference, with NREM and REM sleep affecting sociality and novelty preference respectively.

This study investigates how VTA-GABAergic neurons change their activity across sleep/wake states and in response to stimuli, showing distinct correlations with cortical oscillations compared to dopaminergic neurons.