Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals
Salah Mahmoudi, Elena Mancini, Alessandra Moore, Lucy Xu, Fereshteh Jahanbani, Katja Hebestreit, Rajini Srinivasan, Xiyan Li, Keerthana Devarajan, Laurie Prélot, Cheen Euong Ang, Yohei Shibuya, Bérénice A. Benayoun, Anne Lynn S. Chang, Marius Wernig, , Anne Brunet
This study shows that old fibroblasts secrete inflammatory cytokines, leading to variability in reprogramming efficiency and affecting wound healing in older individuals.
bioRxiv · Oct 19, 2018 · PreprintCell Biology