Katja Hebestreit

The paper identifies prion-like and phase-separated protein aggregates in aging vertebrate brains using quantitative proteomics in killifish and validates their propagation and functional properties.

The paper analyzes single-cell transcriptomics data from Parkinson's Disease patients and controls to identify cell type-specific molecular responses and pathways involved in neurodegeneration.

The paper introduces scCoExpNets and CovCoExpNets to analyze cell-type specific gene co-expression networks from single-cell RNA-seq data, identifying iron accumulation as a factor in dopaminergic neuron vulnerability in Parkinson's disease.

The paper investigates how male sexual interactions negatively affect female and hermaphrodite lifespan in C. elegans, uncovering genes involved in male-induced demise and longevity pathways.

This paper introduces BAGEA, a Bayesian framework for analyzing cis-eQTL data using genomic annotations, showing it can predict up to 5% of expression variance for top-effect genes.

This study shows that old fibroblasts secrete inflammatory cytokines, leading to variability in reprogramming efficiency and affecting wound healing in older individuals.