This study tests doxycycline's effect on uveal melanoma in a human ocular organoid model, finding it inhibits growth, angiogenesis, and oxidative phosphorylation in BAP1-repressed cells.

bioRxiv · Jul 28, 2026 · PreprintCancer Biology

Potential modes of COVID-19 transmission from human eye revealed by single-cell atlas

Pradeep Gautam, Kiyofumi Hamashima, Ying Chen, Yingying Zeng, Bar Makovoz, Bhav Harshad Parikh, Hsin Yee Lee, Katherine Anne Lau, Xinyi Su, Raymond C.B. Wong, Woon‐Khiong Chan, Hu Li, Timothy A. Blenkinsop, Yuin‐Han Loh

The paper identifies conjunctival cells as potential entry points for SARS-CoV-2 by showing they express both ACE2 and TMPRSS2 receptors.

Nature Communications · Sep 28, 2021Peer-reviewedGenomics

FOXS1 is a Master Regulator of Pathological Epithelial to Mesenchymal Transition in Human Epithelia

Timothy A Blenkinsop, Tomasz Swigut, Nathan Boles, Rajini Srinivasan, Alvaro Rada-Iglesias, Qingjie Wang, Jeffrey H Stern, Joanna Wysocka, Sally Temple

The paper identifies FOXS1 as a master regulator of EMT in human epithelia, showing its role in driving transcriptional and epigenetic changes and its involvement in cancer.

bioRxiv · Jun 26, 2017 · PreprintCell Biology