Yohei Shibuya

This study uses heterochronic myeloid cell replacement to show that the local brain environment, not intrinsic factors, drives microglia aging.

This study identifies a neuroprotective myeloid state in MS and EAE models, showing that HCT enhances this state, leading to clinical improvement and reduced demyelination.

This study shows that old fibroblasts secrete inflammatory cytokines, leading to variability in reprogramming efficiency and affecting wound healing in older individuals.