Dual Role of Cx43 in Enhancing CDK4/6 Inhibitor Response and Promoting the Elimination of Therapy-Induced Senescent Tumor Cells
Paula Carpintero-Fernández, Marta Barturen-Gómez, Vanesa Álvarez, Alexander Carneiro-Figueira, Soumadipta Mazumdar, Loretta De Chiara, Alejandro García-Yuste, MF Soler, Susana B. Bravo, Joaquin Mosquera, Benigno Acea, Carlos Fernandez-Lozano, María M. Caffarel, Constance Alabert, María D. Mayán
This paper identifies Cx43 as a target that enhances CDK4/6 inhibitor efficacy and promotes elimination of therapy-induced senescent tumor cells through senolytic agents.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology