Constance Alabert

Dual Role of Cx43 in Enhancing CDK4/6 Inhibitor Response and Promoting the Elimination of Therapy-Induced Senescent Tumor Cells

This paper identifies Cx43 as a target that enhances CDK4/6 inhibitor efficacy and promotes elimination of therapy-induced senescent tumor cells through senolytic agents.

DNA methylation links lagging strand replication to transposable element control

The paper shows DNA methylation maintenance is linked to lagging-strand replication and TE control in mouse cells, with TE integration preferentially occurring on the lagging strand.

Chromatin assembly at replication forks enables differentiation of human iPSCs

This study shows DNA replication enables chromatin changes during human iPSC differentiation by allowing protein access to nascent DNA, with H3K9 methylation and proteins like ERH and SETDB1 playing key roles.

RIF1 orchestrates a multi-step restoration of post-replicative H3K9me3

This study identifies RIF1's role in restoring H3K9me3 post-replication by facilitating SUV39H1, HP1, and PP1 recruitment and restraining Aurora kinase activity.

Cx43 Enhances Response to BRAF/MEK Inhibitors by Reducing DNA Repair Capacity

This study shows that Cx43 enhances the effectiveness of BRAF/MEKi by reducing DNA repair, leading to increased DNA damage and cellular senescence, and proposes a novel therapeutic approach using sEVs.

PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression

This study identifies PHD1-dependent hydroxylation of RepoMan at P604, showing it regulates mitotic progression by modulating PP2A interaction and H3T3 phosphorylation.

Supervised and unsupervised deep learning-based approaches for studying DNA replication spatiotemporal dynamics

This study uses supervised and unsupervised deep learning to analyze DNA replication dynamics in mouse cells, identifying altered patterns in Rif1-deficient cells and extending to patient samples.

FAM111A regulates replication origin activation and cell fitness

This study identifies FAM111A as a regulator of DNA replication origin activation and shows its interaction with FAM111B and HMCES, with implications for disease when its peptidase domain is intact.

Transcription promotes the restoration of chromatin following DNA replication.

This study shows that transcription restart after DNA replication promotes chromatin reestablishment but is also linked to genotoxic stress.

Domain model explains propagation dynamics and stability of K27 and K36 methylation landscapes

The paper models the propagation and stability of K27 and K36 methylation landscapes using computational methods and mass spectrometry data.