Vanesa Álvarez

This paper identifies Cx43 as a target that enhances CDK4/6 inhibitor efficacy and promotes elimination of therapy-induced senescent tumor cells through senolytic agents.

This study shows that Cx43 enhances the effectiveness of BRAF/MEKi by reducing DNA repair, leading to increased DNA damage and cellular senescence, and proposes a novel therapeutic approach using sEVs.

This study identifies PHD1-dependent hydroxylation of RepoMan at P604, showing it regulates mitotic progression by modulating PP2A interaction and H3T3 phosphorylation.

This study identifies FAM111A as a regulator of DNA replication origin activation and shows its interaction with FAM111B and HMCES, with implications for disease when its peptidase domain is intact.

This study shows that transcription restart after DNA replication promotes chromatin reestablishment but is also linked to genotoxic stress.