Discovery of non-nucleoside inhibitors of the enterovirus D68 3D polymerase through crystallographic fragment and high-throughput biochemical screening
Iman Biswas, Qinghui Wang, Jack T. McCann, Egor P. Tchesnokov, Linh Nguyen, Manisha Saini, Jocelyn Cantero, Jezrael L. Revalde, Matthias Götte, Adam R. Renslo, R. Jeffrey Neitz, Michelle R. Arkin, Eddy Arnold, Francesc X. Ruiz
This study identifies non-nucleoside inhibitors of EV-D68 3D polymerase through crystallographic fragment and high-throughput screening, revealing potential drug targets and lead compounds.
bioRxiv · Jul 10, 2026 · PreprintBiophysics