Jezrael L. Revalde

This study identifies small molecule inhibitors of APOBEC3A and APOBEC3B using a fluorescence polarization assay, revealing compounds that disrupt DNA interactions and deaminase activity.

This study identifies non-nucleoside inhibitors of EV-D68 3D polymerase through crystallographic fragment and high-throughput screening, revealing potential drug targets and lead compounds.

This paper describes the discovery of new coronavirus MPro inhibitors with improved pharmacokinetics, broad-spectrum antiviral activity, and superior in vivo efficacy compared to existing drugs.

This study identifies DDX3X's role in translation by developing HART, a reporter that measures DDX3X-dependent translational activity and reveals structural and functional determinants of its sensitivity.

The paper investigates the functional consequences of SLC6A1 variants, finding haploinsufficiency underlies neurodevelopmental phenotypes and identifying missense residues sensitive to substitution.