Deep-learning-based design of an orthogonal self-labeling protein from K-Ras(G12C)
Jody Mou, Jing Wesley Leong, Sean Gao, Kaia Slaw, Michael McGill, Katherine A. Donovan, Rebecca J. Metivier, Franziska L. Sendker, Qi Kong, Diangen Lin, Azim M. Dharani, Xi Dawn Chen, Kevin M. Haigis, Eric S. Fischer, Fei Chen, Nicholas F. Polizzi
This paper designs an orthogonal self-labeling protein, LUCI-tag, using deep learning, which enables rapid and payload-agnostic labeling of proteins in live cells.
bioRxiv · Sep 29, 2026 · PreprintBioengineering