Author

Jing Wesley Leong

Broad InstituteORCID 0009-0003-8374-0898Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:long-read sequencing· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:scRNA-seq· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Fei CheniD· 2 shared Xi Dawn CheniD· 2 shared Andrea Navarro TorresiD· 1 shared Anisha LaumasiD· 1 shared Azim M. DharaniiD· 1 shared David Wollensak· 1 shared Diangen LiniD· 1 shared Eric S. FischeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

Fei ChenORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintSep 29, 2026

Deep-learning-based design of an orthogonal self-labeling protein from K-Ras(G12C)

Jody Mou, Jing Wesley Leong, Sean Gao…·Nicholas F. Polizzi

This paper designs an orthogonal self-labeling protein, LUCI-tag, using deep learning, which enables rapid and payload-agnostic labeling of proteins in live cells.

DOI 10.64898/2026.09.27.754867

protein structuredeep learning

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Molecular BiologybioRxivPreprintNov 5, 2025

Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation

Xi Dawn Chen, Manson Jim, Mounica Vallurupalli…·Fei Chen

The paper introduces SPICE, a framework that uses splicing assays and generative design to create cell-specific gene regulation elements for research and therapy.

4 citations

humanscRNA-seq

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