Author

Azim M. Dharani

Harvard UniversityORCID 0000-0003-2012-146XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:protein design· 1

Frequent Co-Authors

Anush Chiappino-PepeiD· 1 shared Bogdan BudnikiD· 1 shared Diangen LiniD· 1 shared Eric S. FischeriD· 1 shared Erkin KuruiD· 1 shared Fei CheniD· 1 shared Felix RadfordiD· 1 shared Franziska L. SendkeriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSynthetic Biology

Anush Chiappino-PepeORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Deep-learning-based design of an orthogonal self-labeling protein from K-Ras(G12C)

Jody Mou, Jing Wesley Leong, Sean Gao, Kaia Slaw, Michael McGill, Katherine A. Donovan, Rebecca J. Metivier, Franziska L. Sendker, Qi Kong, Diangen Lin, Azim M. Dharani, Xi Dawn Chen, Kevin M. Haigis, Eric S. Fischer, Fei Chen, Nicholas F. Polizzi

This paper designs an orthogonal self-labeling protein, LUCI-tag, using deep learning, which enables rapid and payload-agnostic labeling of proteins in live cells.

bioRxiv · Sep 29, 2026 · PreprintBioengineering

Preventing escape and malfunction of recoded cells due to tRNA base changes

Anush Chiappino-Pepe, Felix Radford, Bogdan Budnik, Hüseyin Taş, Teresa L. Augustin, Hana M Burgess, Michaël Moret, Azim M. Dharani, Qinmei Zheng, Weicheng Fan, Maksud M Africawala, Shova Thapa, Erkin Kuru, Kamesh Narasimhan, Jorge A. Marchand, , George McDonald Church

The paper shows recoded E. coli can escape faster due to tRNA base changes and introduces kill switches to prevent this.

bioRxiv · Jul 18, 2024 · PreprintSynthetic Biology