Author

Sean Gao

Harvard UniversityORCID 0000-0003-2316-9207Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Eric S. FischeriD· 2 shared Azim M. DharaniiD· 1 shared Diangen LiniD· 1 shared Dingjingyu Zhou· 1 shared Fei CheniD· 1 shared Franziska L. SendkeriD· 1 shared Jing Wesley LeongiD· 1 shared Jody Mou· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

Eric S. FischerORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintSep 29, 2026

Deep-learning-based design of an orthogonal self-labeling protein from K-Ras(G12C)

Jody Mou, Jing Wesley Leong, Sean Gao…·Nicholas F. Polizzi

This paper designs an orthogonal self-labeling protein, LUCI-tag, using deep learning, which enables rapid and payload-agnostic labeling of proteins in live cells.

DOI 10.64898/2026.09.27.754867

protein structuredeep learning

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BioengineeringbioRxivPreprintMay 10, 2026

Z-TAC enables custom and combinatorial degradation of cell surface proteins

Dingjingyu Zhou, Lawrence Shue, Sean H Gao…·Xin X. Zhou

Z-TAC converts IgG antibodies into cell-surface protein degraders, enabling efficient and sustained degradation of multiple receptors and receptor combinations.

1 citation

experimental assaydrug response / drug discovery

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