Author

Joe J. Solvason

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1

Frequent Co-Authors

Emma K. FarleyiD· 3 shared Adam KlieiD· 2 shared Fabian LimiD· 2 shared Sophia H. LeiD· 2 shared Agnieszka D’Antonio‐ChronowskaiD· 1 shared Alexis BantleiD· 1 shared Genevieve E. RyaniD· 1 shared Granton A. JindaliD· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBioinformatics

Emma K. FarleyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

EUGENe: A Python toolkit for predictive analyses of regulatory sequences

Adam Klie, Hayden Stites, Tobias Jores, Joe J. Solvason, Emma K. Farley, Hannah K. Carter

EUGENe is a FAIR Python toolkit for deep learning analysis of regulatory sequences, offering modular tools for data handling, model training, and evaluation.

bioRxiv · Oct 24, 2022 · PreprintBioinformatics

Affinity-optimizing variants within the ZRS enhancer disrupt limb development

Fabian Lim, Genevieve E. Ryan, Sophia H. Le, Joe J. Solvason, Paige Steffen, Emma K. Farley

The paper shows that optimizing low-affinity ETS binding sites in the ZRS enhancer causes limb development defects, with severity increasing with higher affinity gains.

bioRxiv · May 27, 2022 · PreprintGenetics

Affinity-optimizing variants within cardiac enhancers disrupt heart development and contribute to cardiac traits

Granton A. Jindal, Alexis Bantle, Joe J. Solvason, Jessica L. Grudzien, Agnieszka D’Antonio‐Chronowska, Fabian Lim, Sophia H. Le, Reid O. Larsen, Adam Klie, Kelly A. Frazer, Emma K. Farley

The paper identifies ETS affinity-optimizing SNVs in heart enhancers that disrupt development and contribute to cardiac traits in Ciona and human iPSC-CMs.

bioRxiv · May 27, 2022 · PreprintGenomics