GeneticsbioRxivPreprint
Affinity-optimizing variants within the ZRS enhancer disrupt limb development
Fabian Lim, Genevieve E. Ryan, Sophia H. Le…·Emma K. Farley
The paper shows that optimizing low-affinity ETS binding sites in the ZRS enhancer causes limb development defects, with severity increasing with higher affinity gains.
7 citations