Tensor-cell2cell v2 jointly analyzes protein- and metabolite-mediated cell-cell communication over time, revealing coordinated dynamics in brain organoid development.

Bioinformatics · Feb 1, 2026Peer-reviewedSystems Biology

Multi-omic analysis reveals the unique glycan landscape of the blood-brain barrier glycocalyx

Reid O. Larsen, Krzysztof Kucharz, Sidar Aydin, Mariel Kristine B Micael, Biswa Choudhury, Mousumi Paulchakrabarti, Micael Lønstrup, Donghai Lin, Markus Abeln, Anja Münster-Kühnel, Alejandro Gómez Toledo, Martin Lauritzen, Jeffrey D. Esko, Richard Daneman

The paper analyzes the BBB glycocalyx using multi-omic approaches, revealing unique glycan composition and structural features, and their potential role in neuroinflammation.

bioRxiv · Apr 7, 2025 · PreprintMolecular Biology

Affinity-optimizing variants within cardiac enhancers disrupt heart development and contribute to cardiac traits

Granton A. Jindal, Alexis Bantle, Joe J. Solvason, Jessica L. Grudzien, Agnieszka D’Antonio‐Chronowska, Fabian Lim, Sophia H. Le, Reid O. Larsen, Adam Klie, Kelly A. Frazer, Emma K. Farley

The paper identifies ETS affinity-optimizing SNVs in heart enhancers that disrupt development and contribute to cardiac traits in Ciona and human iPSC-CMs.

bioRxiv · May 27, 2022 · PreprintGenomics