The nucleotide analog bemnifosbuvir inhibits hepatitis E virus replication in preclinical models
Jungen Hu, Tianxu Liu, Mara Klöhn, Andrew Freistaedter, Elif Toprak, Huanting Chi, Paula Jordan, Xinyue Yang, Johanna Becker, Volker Lohmann, Eike Steinmann, Lin Wang, Viet Loan Dao Thi
This study identifies bemnifosbuvir as a potent inhibitor of hepatitis E virus replication in vitro and in a gerbil model, with additive effects when combined with ribavirin.
bioRxiv · Aug 15, 2025 · PreprintMicrobiology