Author

Jungen Hu

Heidelberg UniversityORCID 0000-0002-2132-0770Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Viet Loan Dao ThiiD· 2 shared Ana Luisa CostaiD· 1 shared Andrew FreistaedteriD· 1 shared Ann-Kathrin MehnertiD· 1 shared Carl HerrmanniD· 1 shared Carla Siebenkotten· 1 shared Carlos Darío RamíreziD· 1 shared Daniel Kirrmaier· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Viet Loan Dao ThiORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

The nucleotide analog bemnifosbuvir inhibits hepatitis E virus replication in preclinical models

Jungen Hu, Tianxu Liu, Mara Klöhn, Andrew Freistaedter, Elif Toprak, Huanting Chi, Paula Jordan, Xinyue Yang, Johanna Becker, Volker Lohmann, Eike Steinmann, Lin Wang, Viet Loan Dao Thi

This study identifies bemnifosbuvir as a potent inhibitor of hepatitis E virus replication in vitro and in a gerbil model, with additive effects when combined with ribavirin.

bioRxiv · Aug 15, 2025 · PreprintMicrobiology

The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistence in hepatocytes

Ann-Kathrin Mehnert, Sebastian Stegmaier, Carlos Darío Ramírez, Vladimir Gonçalves Magalhães, Carla Siebenkotten, Jungen Hu, Ana Luisa Costa, Daniel Kirrmaier, Michael Knop, Xianfang Wu, Thibault Tubiana, Carl Herrmann, Marco Binder, Viet Loan Dao Thi

This study identifies ORF2 as a key HEV protein that suppresses antiviral responses in hepatocytes, enabling viral persistence.

bioRxiv · Feb 3, 2025 · PreprintMicrobiology