Eike Steinmann

Impact of hepatitis E virus host- and virus-derived insertions on the antiviral response in primary human hepatocytes

This study examines how different HEV HVR insertion variants affect host transcriptomic responses in PHHs, finding that HVR duplication variants elicit weaker host responses and reduced ISG induction.

Yellow fever vaccine propagation in primary human hepatocytes triggers antiviral and cytolytic responses

This study compares antiviral and cytolytic responses in primary human hepatocytes to YFV vaccine and virulent strains, finding similar propagation kinetics but distinct transcriptional responses.

The nucleotide analog bemnifosbuvir inhibits hepatitis E virus replication in preclinical models

This study identifies bemnifosbuvir as a potent inhibitor of hepatitis E virus replication in vitro and in a gerbil model, with additive effects when combined with ribavirin.

Glycyrrhizin effectively neutralizes SARS-CoV-2 in vitro by inhibiting the viral main protease

This study shows glycyrrhizin inhibits SARS-CoV-2 main protease and neutralizes the virus in vitro, suggesting it as a potential antiviral treatment for COVID-19.