Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function
Anne Bormann, Marek B. Körner, Anne-Kristin Dahse, Marie S. Gläser, Johanna Irmer, Vera Lede, Judith Alenfelder, Joris Lehmann, Daniella C. N. Hall, Michael Thane, Michael H. Schleyer, Evi Kostenis, Torsten Schöneberg, Marina Bigl, Tobias Langenhan, , Nicole Scholz
The paper shows that intron retention generates single transmembrane-helix isoforms of aGPCRs, enabling mechanosensory function through heteromerization with 7TM subunits.
bioRxiv · Jan 11, 2023 · PreprintNeuroscience