Tobias Langenhan

This study investigates the mechanotransduction mechanism of ADGRG1/GPR56, revealing a dual-mode activation process that does not require NTF-CTF dissociation and depends on the Stachel element.

This paper identifies Polycystin-1 as an atypical adhesion GPCR that activates a signaling pathway through Wnt ligands and mechanical stimuli, leading to GSK3 inhibition and ciliary removal.

This study shows that overexpression of the Drosophila Bchs gene, an ortholog of human WDFY3, causes neural developmental issues in both neurons and glial cells, mirroring human neurodevelopmental disorders.

This study identifies DH31-positive clock neurons in the DN1p cluster that regulate memory performance through both direct and indirect signaling mechanisms.

The paper shows that intron retention generates single transmembrane-helix isoforms of aGPCRs, enabling mechanosensory function through heteromerization with 7TM subunits.

The paper identifies altered gene expression patterns in 15q13.3 microdeletion carriers, showing dysregulation of genes involved in brain development and contributing to phenotypic variability.

This study identifies Complexin as a conserved vesicular protein that interacts with Bruchpilot's C-terminus to tether synaptic vesicles to the active zone cytomatrix in Drosophila and mouse synapses.