Author

John Butler

University of Southampton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:virus· 1

Frequent Co-Authors

Max CrispiniD· 4 shared Joel D. AlleniD· 3 shared Maddy L. NewbyiD· 3 shared Elisa FaddaiD· 2 shared Francesco ForconiiD· 2 shared Patrick J. DurieziD· 2 shared Abigail S. L. SudoliD· 1 shared Adnan AzimiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersMolecular Biology

Max CrispinORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase

Marium Khaleque, Beatrice Tropea, Ojas Singh, Danila Elango, Shulei Liu, Joel D. Allen, Maddy L. Newby, Abigail S. L. Sudol, Jacob T. Willcox, John Butler, Patrick J. Duriez, Francesco Forconi, Ivo Tews, Amanda S. Nouwens, Max Crispin, , Benjamin Luke Schulz

This paper identifies sequence determinants that regulate oligosaccharyltransferase (OST) catalytic efficiency and glycosylation specificity in proteins.

bioRxiv · Sep 6, 2025 · PreprintBiochemistry

The Origin, Diagnosis, and Prognosis of Oligomannose-Type Diffuse Large B Cell Lymphoma

Dylan J. Tatterton, Maddy L. Newby, Joel D. Allen, Benjamin Sale, Giorgia Chiodin, Patrick J. Duriez, John Butler, Katy J. McCann, David W. Scott, Ryan D. Morin, Kostiantyn Dreval, Andrew John Davies, Dean J. Bryant, Max Crispin, Francesco Forconi

This paper identifies Mann-type DLBCL as a subtype of GCB-DLBCL characterized by oligomannose-type glycans in CDR-located AGS, associated with poor prognosis and distinct gene expression patterns.

Blood · Sep 2, 2025Peer-reviewedCancer Biology

Natural variations within the glycan shield of SARS-CoV-2 impact viral spike dynamics

Maddy L. Newby, Carl A. Fogarty, Joel D. Allen, John Butler, Elisa Fadda, Max Crispin

The paper examines how natural variations in SARS-CoV-2 glycan sites affect spike protein dynamics and antigenic structure through molecular dynamics and structural modeling.

Journal of Molecular Biology · Dec 21, 2022Peer-reviewedMolecular Biology

A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection

Cornelia Blume, Claire L. Jackson, Cosma Mirella Spalluto, Jelmer Legebeke, Liliya Nazlamova, Franco Conforti, Jeanne‐Marie Perotin, Martin Frank, John Butler, Max Crispin, Janice L. Coles, James Thompson, Robert A. Ridley, Lareb S. N. Dean, Matthew Loxham, , Vito Mennella

The paper identifies a novel short ACE2 isoform expressed in respiratory epithelia that is upregulated by interferon and RNA virus infection but not SARS-CoV-2, and shows reduced SARS-CoV-2 binding affinity.

Nature Genetics · Jan 11, 2021Peer-reviewedMolecular Biology