mTORC1 activation drives astrocyte reactivity in cortical tubers and brain organoid models of TSC
Thomas L. Li, John D. Blair, Taesun Yoo, Gerald Arthur Grant, Dirk F. Hockemeyer, Brenda E. Porter, Helen S. Bateup
This study shows that mTORC1 activation in astrocytes drives reactivity in cortical tubers and brain organoids, linking it to TSC pathology.
bioRxiv · Feb 28, 2025 · PreprintNeuroscience