SHANK3-CAMSAP2 interaction links synapses to dendritic microtubule organisation in PV neurons
Daniela Hacker, Suho Lee, Michael Hecht-Bucher, Sangmun Lee, Caspar S. Lamborelle, Alois Nathanael Doil, Tomas Fanutza, Arie Maeve Brueckner, Taesun Yoo, Sacnicte Ramírez‐Ríos, Cezary Smaczniak, Kerstin Kaufmann, Dick H. W. Dekkers, Jeroen Demmers, Marie‐Jo Moutin, , Marina Mikhaylova
The paper shows that the SHANK3-CAMSAP2 interaction links synapses to dendritic microtubule organisation in parvalbumin neurons, with the SHANK3L68P mutation enhancing this interaction and altering microtubule dynamics.
bioRxiv · Feb 11, 2026 · PreprintNeuroscience