In Vivo Production of a Protein via the Delivery of Plasmid DNA by Computationally Designed Polymer Nanoparticles (PNP)
John D. Fisher, Shannon R. Petersen, Olivia Heynes, Suteja Patil, Teresa Tamayo-Mendoza, Felipe Oviedo, Gustavo Guzman, Jared Van Reet, Jeffrey Ting, Sean Kevlahan, Thomas X. Neenan, Shashi K. Murthy
This paper demonstrates the design of polymer nanoparticles (PNPs) for in vivo delivery of plasmid DNA encoding a broadly neutralizing anti-HIV antibody, achieving durable protein expression levels.
bioRxiv · Feb 14, 2025 · PreprintBioengineering