Sequential increase of PHGDH expression with Alzheimer's pathology and symptoms
Xu Chen, Riccardo Calandrelli, John Girardini, Zhangming Yan, Zhiqun Tan, Xiangmin Xu, Annie OF Hiniker, Sheng Zhong
The paper shows PHGDH expression increases sequentially with AD pathology and symptoms in mice and humans, correlating with cognitive decline and suggesting PHGDH as a potential biomarker and caution for L-serine therapy.
bioRxiv · Feb 15, 2022 · PreprintNeuroscience