Zhangming Yan

This study investigates how chromatin-associated RNA interacts with 3D genome organization in human cells, revealing a feedback loop between RNA distribution and chromatin structure.

The paper shows PHGDH expression increases sequentially with AD pathology and symptoms in mice and humans, correlating with cognitive decline and suggesting PHGDH as a potential biomarker and caution for L-serine therapy.

The paper identifies SMARCA4 and ERK-ETS signaling as targets for suppressing aging-related dopaminergic degeneration in Parkinson's disease using gene co-expression analysis and Drosophila models.

The paper identifies a correlation between RNA-DNA interactions in normal cells and fusion RNA pairs in cancer, suggesting a mechanism for fusion transcript formation.

GIVE provides a library for creating personalized genome browsers on personal websites without needing system administration.

The paper identifies genomic regions proximal to nuclear speckles using noncoding RNAs and MARGI assay, showing nsaRNAs interact with specific genomic sites.